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Spanning three generations of a Japanese American family, 45 years separates filmmaker Ann Kaneko from her mother and from her daughter and 90 years distance grandparents and grandchild. 45/45 weaves together a tapestry of images and observations, chronicling and celebrating growing up and growing old. Parents and children reverse roles as the “sandwiched” daughter, who doubles as filmmaker and caregiver, shares insights about the uncanny resemblance of life’s beginning and end. Everyday moments filled with the exuberance of youth contrast with accidents of a failing body, showing the preciousness of intergenerational relations and caregiving that supports these life cycles.